The wide use and even abuse of antimicrobial agents in human medicine and agriculture has led to severe widespread antimicrobial resistance, causing reduced effectiveness or even ineffectiveness of many antibacterial agents. This is of major public concern since most areas of modern medicine are inconceivable without access to effective antimicrobial treatment. There is an urgent and imperative need to develop novel therapeutics for treating infectious diseases caused by multidrug-resistant microorganisms. The past decade has witnessed the global exploration of plant-based antimicrobials as an alternative to therapeutic antibiotics by scientists. This study aims to investigate the potential antibacterial activity of medicinal plant infusions against Salmonella enterica (NCTC 13349) and E. coli (NCTC 11560 and 13352). The broth microdilution and checkerboard methods in 96-well plates were used to determine the susceptibility of the pathogens to the infusions and their combination therapy with antibiotics, respectively. Fifteen plants producing nineteen different infusions (different parts of some plants were used) were used based on their traditional knowledge and antibacterial activity in scientific literature. Preliminary antibacterial results showed that the infusions showed varying antibacterial activity, with the minimum inhibitory concentration ranging between 0.078 and 10 mg/mL. However, only eight of the infusions (42.1%) showed moderate activity against the pathogens. In addition, significant combination therapy was observed between seven of the plant infusions and erythromycin and penicillin against the pathogens. In combination, plant infusions reduced the MIC of the antibiotics up to 500 fold, resulting in 99%, potency. Further studies are needed to determine the likely modes of action and safety profile of these plant infusions.